Synthesis of alpha-methyl-4-(2-thienylcarbonyl)benzeneacetic acid, suprofen, and derivatives.
作者信息
Van Daele P G, Boey J M, Sipido V K, De Bruyn M F, Janssen P A
出版信息
Arzneimittelforschung. 1975 Oct;25(10):1495-1501.
PMID:1243027
Abstract
A series of compounds with general structure Het-CO-Ar-CH(CH3)COOH was prepared for pharmacological screening. Different synthetic approaches are described. Alpha-Methyl-4-(2-thienylcarbonyl)benzeneacetic acid (compound III-1, suprofen) was found to show a marked antiwrithing activity. Furthermore this compound proved to be a potent inhibitor of prostaglandin biosynthesis.
摘要
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