Todd P A, Heel R C
Drugs. 1985 Dec;30(6):514-38. doi: 10.2165/00003495-198530060-00004.
Suprofen (sutoprofen) is a non-steroidal anti-inflammatory analgesic, closely related structurally to drugs such as ibuprofen, ketoprofen and naproxen. In patients with acute pain, single oral doses of suprofen are at least as effective as: usual therapeutic doses of aspirin; codeine alone or combined with aspirin; dextropropoxyphene alone or in various combinations; oxycodone combined with aspirin; dipyrone; pentazocine; paracetamol (acetaminophen); diflunisal; ibuprofen; indomethacin; or mefenamic acid. In chronic pain due to osteoarthritis, suprofen is as effective as usual dosages of aspirin or dextropropoxyphene during long term therapy, and as effective as diclofenac, ibuprofen, indomethacin and naproxen during short term treatment. As with other non-steroidal anti-inflammatory drugs, gastrointestinal complaints are the most frequently reported side effects, although discontinuation due to gastrointestinal effects may be necessary less frequently with suprofen than with aspirin, dextropropoxyphene or combinations of the two. Suprofen appears to be a useful alternative to mild analgesics, analgesic combinations or the older more established non-steroidal anti-inflammatory drugs in the treatment of patients with acute or chronic pain. However, further definition of its efficacy and tolerability is required, especially in comparison with newer non-steroidal anti-inflammatory analgesics.
舒洛芬是一种非甾体抗炎镇痛药，在结构上与布洛芬、酮洛芬和萘普生等药物密切相关。在急性疼痛患者中，单次口服舒洛芬的效果至少与以下药物相当：阿司匹林的常用治疗剂量；单独使用的可待因或与阿司匹林联用；单独使用或多种组合使用的右丙氧芬；与阿司匹林联用的羟考酮；安乃近；喷他佐辛；对乙酰氨基酚；双氟尼酸；布洛芬；吲哚美辛；或甲芬那酸。在骨关节炎引起的慢性疼痛中，舒洛芬在长期治疗中与阿司匹林或右丙氧芬的常用剂量效果相当，在短期治疗中与双氯芬酸、布洛芬、吲哚美辛和萘普生效果相当。与其他非甾体抗炎药一样，胃肠道不适是最常报告的副作用，不过因胃肠道反应而停药的必要性在舒洛芬治疗时可能比阿司匹林、右丙氧芬或两者联用的情况更少。在治疗急性或慢性疼痛患者时，舒洛芬似乎是轻度镇痛药、镇痛组合药物或更老牌的非甾体抗炎药的有用替代药物。然而，需要进一步明确其疗效和耐受性，尤其是与更新的非甾体抗炎镇痛药相比。
