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[Optimating the availability of homologous quaternary ammonium compounds/3rd communication: The influence of salts on in vitro distribution of benzilic acid esters of homologous dimethyl-(2-hydroxyethyl)-alkyl-ammoniumbromides (author's transl)].

作者信息

Lippold B C, Schneider G F

出版信息

Arzneimittelforschung. 1975 Nov;25(11):1683-6.

PMID:1243073
Abstract

The addition of NaBr, Na-butansulfonate or Na-trichloracetat increases the partition coefficients of homologous quaternary cholinesters of benzilic acid between n-octanol and water. In a three-phase model (water/n-octanol/water) thus the rates of equilibration increase considerably for hydrophilic compounds.

摘要

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