Hide Michihiro, Tanaka Toshihiko, Yamamura Yumi, Koro Osamu, Yamamoto Shoso
Department of Dermatology, Graduate School of Biomedical Sciences, Hiroshima University, Japan.
Acta Derm Venereol. 2002;82(5):335-40. doi: 10.1080/000155502320624050.
Sweating aggravates itch in atopic dermatitis, but the mechanism is unclear. In this study, we examined the involvement of type I hypersensitivity in the aggravation of atopic dermatitis by sweating. Skin tests with autologous sweat were positive in 56 of 66 patients (84.4%) with atopic dermatitis, but only in 3 of 27 healthy volunteers (11.1%). Sweat samples from both patients and healthy volunteers induced varying degrees of histamine release from basophils of patients with atopic dermatitis. However, the histamine release was impaired by removal of IgE on the basophils. Incubation of basophils with myeloma IgE before sensitization with serum of patients blocked the ability to release histamine-induced sweat. IgE antibody against antigen(s) in sweat may be present in serum of patients with atopic dermatitis. Key words:
出汗会加重特应性皮炎的瘙痒，但机制尚不清楚。在本研究中，我们研究了Ⅰ型超敏反应在出汗加重特应性皮炎中的作用。66例特应性皮炎患者中有56例（84.4%）对自体汗液皮肤试验呈阳性，而27名健康志愿者中只有3例（11.1%）呈阳性。来自患者和健康志愿者的汗液样本均可诱导特应性皮炎患者嗜碱性粒细胞释放不同程度的组胺。然而，嗜碱性粒细胞上的IgE去除后，组胺释放受到损害。在用患者血清致敏前，用骨髓瘤IgE孵育嗜碱性粒细胞可阻断汗液诱导组胺释放的能力。特应性皮炎患者血清中可能存在针对汗液中抗原的IgE抗体。关键词：
