形态学、细胞化学和免疫组织化学在慢性骨髓增殖性疾病诊断中的作用。
The role of morphology, cytochemistry and immunohistochemistry in the diagnosis of chronic myeloproliferative diseases.
作者信息
Li Chin-Yang
机构信息
Mayo Clinic, Rochester, Minnesota, USA.
出版信息
Int J Hematol. 2002 Aug;76 Suppl 2:6-8. doi: 10.1007/BF03165077.
Chronic myeloprolifeative diseases (CMPD) are clonal hematopoietic stem cell disorders characterized by excessive proliferation and production of one or more of the myeloid cells and are subclassified according to the predominant cells, such as chronic myelogenous leukemia (CNL), chronic eosinophilic leukemia (CEL), polycythemia vera (PV), essential thrombocythemia (ET) and chronic idiopathic myelofibrosis (CIMF). This brief review focuses on the characteristic morphology of each clinical entity and the useful cytochemical (including leukocyte alkaline phosphatase, myeloperoxidase, butyrate esterase, chloroacetate esterase and cyanide-resistant peroxidase) and immunohistochemical (including von Willebrand factor/CD61, keratin, tryptase, CD117, CD68 (PGM-1), c-Mpl and bFGF) stains for differential diagnosis.
慢性骨髓增殖性疾病（CMPD）是克隆性造血干细胞疾病，其特征为一种或多种髓系细胞过度增殖和生成，并根据主要细胞类型进行亚分类，如慢性粒细胞白血病（CNL）、慢性嗜酸性粒细胞白血病（CEL）、真性红细胞增多症（PV）、原发性血小板增多症（ET）和慢性特发性骨髓纤维化（CIMF）。本简要综述重点关注各临床实体的特征性形态以及用于鉴别诊断的有用细胞化学染色（包括白细胞碱性磷酸酶、髓过氧化物酶、丁酸酯酶、氯乙酸酯酶和抗氰过氧化物酶）和免疫组织化学染色（包括血管性血友病因子/CD61、角蛋白、类胰蛋白酶、CD117、CD68（PGM-1）、c-Mpl和碱性成纤维细胞生长因子）。
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