Concentrations of ampicillin in human urogenital tissue, serum and urine after intake of pivampicillin.

The ampicillin concentrations in serum, urine, kidney, urinary bladder, prostate gland, testis, muscle and skin from 64 urological patients with normal renal function were determined with the agar diffusion method after oral doses of 700 mg of the pivaloyloxymethyl ester of ampicillin (pivampicillin, Pondocillin). The tissue samples were obtained at urological operations, prostatectomy, nephrectomy and orchiectomy. The serum concentration was highest between 2 and 4 h and the urine concentration between 4 and 6 h after intake. The serum concentration was considerably lower than reported in literature, which was shown to 0e due either to the effect of preoperative medication or anesthesia, or to both.