Courtwright Andrew M, He Xiangwei
Department of Biochemistry and Molecular Biology, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston Medical School, 6431 Fannin, 6.200, Houston, TX 77030, USA.
Dev Cell. 2002 Nov;3(5):610-1. doi: 10.1016/s1534-5807(02)00332-5.
Chromosomes have to establish the proper attachment to the spindle before segregation-a process that requires Ipl1p Aurora kinase. Recent work has identified Dam1p, a member of the DASH complex, as the key Ipl1p substrate responsible for kinetochore/microtubule interaction.
染色体在分离之前必须与纺锤体建立正确的附着——这一过程需要Ipl1p极光激酶。最近的研究确定，DASH复合体的成员Dam1p是负责动粒/微管相互作用的关键Ipl1p底物。
