Gibson-Brown Jeremy J
Department of Biology, Washington University, Campus Box 1229, 1 Brookings Drive, Saint Louis, MO 63130, USA.
Dev Cell. 2002 Nov;3(5):625-30. doi: 10.1016/s1534-5807(02)00330-1.
T-box genes encode DNA binding transcription factors known to regulate a wide variety of developmental processes during embryogenesis and are present in the genomes of all multicellular animals. Indeed, alongside other more familiar families of developmental regulators such as Hox, Sox, and Pax, T-box genes constitute one of the fundamental components of the universal metazoan "toolkit" of developmental genes. A recent meeting in Nottingham, England celebrated the first decade of T-box gene research and demonstrated just how much has been learned in the relatively short time since their discovery.