Tada M, Smith J C
Division of Developmental Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom.
Dev Growth Differ. 2001 Feb;43(1):1-11. doi: 10.1046/j.1440-169x.2001.00556.x.
Members of the T-box gene family have been identified in both vertebrates and invertebrates, where they play key roles in the regulation of embryonic development, and particularly in morphogenesis and the assignment of cell fate. T-box proteins act as transcription factors which regulate the expression of downstream effector genes. This review focuses on the identification of T-box target genes and the basis of T-box functional specificity.
T-box基因家族的成员已在脊椎动物和无脊椎动物中被鉴定出来，它们在胚胎发育的调控中发挥关键作用，尤其是在形态发生和细胞命运的确定方面。T-box蛋白作为转录因子，调控下游效应基因的表达。本综述聚焦于T-box靶基因的鉴定以及T-box功能特异性的基础。
