Kinder Leslie S, Kamarck Thomas W, Baum Andrew, Orchard Trevor J
Stanford Center for Research in Disease Prevention, School of Medicine, Stanford University, USA.
Health Psychol. 2002 Nov;21(6):542-52. doi: 10.1037//0278-6133.21.6.542.
Recent evidence has suggested that depressive symptomatology is a risk factor for the development of coronary heart disease (CHD) in patients with diabetes mellitus, although little is understood about mechanisms that may explain this association. The Pittsburgh Epidemiology of Diabetes Complications (EDC) Study is a natural history study of 658 men and women with childhood-onset Type I diabetes. Participants from the EDC Study who reported the fewest depressive symptoms on the Beck Depression Inventory at baseline examination were least likely to develop CHD over 10 years. Differences in insulin resistance, autonomic dysregulation, inflammation, smoking, and complications associated with Type I diabetes appear to help explain this relationship. Future research should clarify causal pathways between depressive symptomatology, behavioral and physiological processes, and CHD.
最近有证据表明，抑郁症状是糖尿病患者患冠心病（CHD）的一个风险因素，尽管对于可能解释这种关联的机制了解甚少。匹兹堡糖尿病并发症流行病学（EDC）研究是一项对658名儿童期发病的1型糖尿病男性和女性进行的自然史研究。在基线检查时，贝克抑郁量表上报告抑郁症状最少的EDC研究参与者在10年内患CHD的可能性最小。胰岛素抵抗、自主神经调节异常、炎症、吸烟以及与1型糖尿病相关的并发症方面的差异似乎有助于解释这种关系。未来的研究应阐明抑郁症状、行为和生理过程与CHD之间的因果途径。
