Dubois Sigrid, Mariner Jennifer, Waldmann Thomas A, Tagaya Yutaka
Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Immunity. 2002 Nov;17(5):537-47. doi: 10.1016/s1074-7613(02)00429-6.
We report intriguing aspects of the contribution of IL-15Ralpha to IL-15 functions. Consistent with high-affinity interactions between IL-15 and IL-15Ralpha, these two molecules form stable complexes on the cell surface of activated monocytes. The formation of IL-15/IL-15Ralpha complexes on cell surfaces induces a trans-endosomal recycling of IL-15 leading to the persistence of surface-bound IL-15 due to the constant reappearance of IL-15 on plasma membranes. This complex contributes to the long survival of T cells expressing IL-15Ralpha after IL-15 withdrawal. Finally, these complexes on activated monocytes present IL-15 in trans to target cells such as CD8(+) T cells that express only IL-2/15Rbeta and gammac upon cell-cell interaction.
我们报告了白细胞介素-15受体α（IL-15Rα）对白细胞介素-15（IL-15）功能贡献的有趣方面。与IL-15和IL-15Rα之间的高亲和力相互作用一致，这两种分子在活化单核细胞的细胞表面形成稳定复合物。细胞表面IL-15/IL-15Rα复合物的形成诱导IL-15的跨内体循环，由于IL-15在质膜上不断重新出现，导致表面结合的IL-15持续存在。这种复合物有助于在撤除IL-15后表达IL-15Rα的T细胞长期存活。最后，活化单核细胞上的这些复合物在细胞间相互作用时将IL-15反式呈递给靶细胞，如仅表达白细胞介素-2/15受体β（IL-2/15Rβ）和γc的CD8(+) T细胞。
