氟代脱氧葡萄糖正电子发射断层扫描在诊断结直肠癌腹膜复发中的应用价值。
Usefulness of FDG-positron emission tomography in diagnosing peritoneal recurrence of colorectal cancer.
作者信息
Tanaka Tomoharu, Kawai Yasuhiro, Kanai Michiyuki, Taki Yoshiro, Nakamoto Yuuji, Takabayashi Arimichi
机构信息
Department of Surgery, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan.
出版信息
Am J Surg. 2002 Nov;184(5):433-6. doi: 10.1016/s0002-9610(02)01004-8.
BACKGROUND
Accurate detection of peritoneal recurrence in colorectal cancer remains a diagnostic challenge. We retrospectively examined sensitivity and accuracy of fluorine-18-2-fluoro-deoxy-D-glucose positron emission tomography (FDG-PET) in the diagnosis of peritoneal recurrence.
METHODS
FDG-PET and computed tomography (CT) were performed on 23 patients with colorectal cancer suspected of having a recurrence based on clinical symptoms, a tumor marker (CEA), and so forth. The final diagnosis was compared with the results of FDG-PET and CT.
RESULTS
Peritoneal recurrence was suspected in 6 patients with FDG-PET, and 5 of them were finally diagnosed as recurrences. The sensitivity of FDG-PET was 88% and its diagnostic accuracy was 78%, whereas those of CT were 38% and 44%, respectively. A lesion as small as 15 mm in diameter was diagnosed by FDG-PET.
CONCLUSIONS
FDG-PET is an effective method for diagnosing peritoneal recurrence of colorectal cancer. FDG-PET is expected to become more important for detecting peritoneal recurrence at an early stage.
背景
准确检测结直肠癌的腹膜复发仍然是一个诊断难题。我们回顾性研究了氟-18-2-氟-脱氧-D-葡萄糖正电子发射断层扫描（FDG-PET）在诊断腹膜复发中的敏感性和准确性。
方法
对23例因临床症状、肿瘤标志物（CEA）等怀疑复发的结直肠癌患者进行了FDG-PET和计算机断层扫描（CT）检查。将最终诊断结果与FDG-PET和CT的结果进行比较。
结果
FDG-PET检查怀疑有6例患者发生腹膜复发，其中5例最终被诊断为复发。FDG-PET的敏感性为88%，诊断准确性为78%，而CT的敏感性和诊断准确性分别为38%和44%。FDG-PET能够诊断出直径小至15毫米的病变。
结论
FDG-PET是诊断结直肠癌腹膜复发的有效方法。FDG-PET有望在早期检测腹膜复发方面发挥更重要的作用。
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