Bao Xin-Min, Shu Si-Yun, Wang Hong
Institute for Neuroscience, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China.
Di Yi Jun Yi Da Xue Xue Bao. 2002 Nov;22(11):961-5.
To investigate the expression of the inhibitory amino acid gamma-aminobutyric acid (GABA) and its receptor GABAR (B1) mRNA in the marginal division of rat striatum.
The expression of GABA and its receptor GABAR (B1) mRNA was studied by way of immunocytochemistry and molecular in situ hybridization method.
Dense GABA-positive immunoreactive fibers and a few positive cells were found in the marginal division of the rat striatum, along with glutamic acid decarboxylase (GAD)-positive fibers and cell bodies. GABA- and GAD-positive cells and fibers were also seen in the cerebral cortex and hippocampus. Numerous cells positive of the expression of GABAR (B1) receptors mRNA were observed in the marginal division whereas only a few positive cells were found in the caudate putamen. GABAR (B1) receptor mRNA expression was also observed in some cells in the cerebral cortex and hippocampus.
The expression of GABA and its receptor in the marginal division of rat striatum indicates a regulatory mechanism of the marginal division of the striatum by GABA, suggesting that GABA can affect the learning and memory function of the marginal division through inhibiting the neurotransmitter release in the presynaptic terminal or modulating the other neurotransmitters.
研究大鼠纹状体边缘区抑制性氨基酸γ-氨基丁酸（GABA）及其受体GABAR（B1）mRNA的表达。
采用免疫细胞化学和分子原位杂交方法研究GABA及其受体GABAR（B1）mRNA的表达。
在大鼠纹状体边缘区发现密集的GABA阳性免疫反应纤维和少量阳性细胞，同时还有谷氨酸脱羧酶（GAD）阳性纤维和细胞体。在大脑皮质和海马中也可见GABA和GAD阳性细胞及纤维。在边缘区观察到大量表达GABAR（B1）受体mRNA的阳性细胞，而在尾壳核中仅发现少量阳性细胞。在大脑皮质和海马的一些细胞中也观察到GABAR（B1）受体mRNA表达。
大鼠纹状体边缘区GABA及其受体的表达表明GABA对纹状体边缘区具有调节机制，提示GABA可通过抑制突触前终末神经递质释放或调节其他神经递质来影响边缘区的学习和记忆功能。
