[不同浓度氮酮对黄芩苷体外透皮吸收的影响]
[Effects of Azone of different concentrations on percutaneous absorption of baicalin in vitro].
作者信息
L Zhi-Ping, Liu Qiang, Lu Xin-Wei
机构信息
Department of Traditional Chinese Medicine, First Military Medical University, Guangzhou 510515, China.
出版信息
Di Yi Jun Yi Da Xue Xue Bao. 2002 Nov;22(11):1003-4.
OBJECTIVE
To study the effects of azone on the percutaneous absorption of baicalin in vitro.
METHODS
Using the skin of nude mice as the cutaneous barrier, the rate constants of percutaneous absorption of baicalin at various concentrations of Azone were determined.
RESULTS
The rate constants were 76.07, 89.23, 167.36, 238.61, 200.45 and 171.49 microgram cm-2.h-1 respectively corresponding to the concentrations of Azone at 0, 2%, 4%, 6%, 8%, and 10%.
CONCLUSION
C Azone can enhance percutaneous absorption of baicalin, exerting its maximum effect at the concentration of 6%.
目的
研究氮酮对黄芩苷体外经皮吸收的影响。
方法
以裸鼠皮肤作为皮肤屏障，测定不同浓度氮酮作用下黄芩苷的经皮吸收速率常数。
结果
氮酮浓度为0、2%、4%、6%、8%和10%时，黄芩苷的经皮吸收速率常数分别为76.07、89.23、167.36、238.61、200.45和171.49μg·cm-2·h-1。
结论
氮酮可促进黄芩苷的经皮吸收，在浓度为6%时作用效果最佳。
Zotero 插件