[Effect of atractylodes rhizome oil and other volatile oils on percutaneous absorption of baicalin].

OBJECTIVE

To study the effects of atractylodes rhizome oil, patchouli oil, angelica volatile oil on the transdermal delivery of baicalin.

METHODS

The modified Valia-Chien diffusion cells was used. With saline isotonic solution as receptor fluid and different concentration of atractylodes rhizome oil, patchouli oil, angelica volatile oil as enhancers, the cumulative amount of baicalin penatrating through the skin was determined in vitro.

RESULTS

All the three volatile oils improved the skin penetration of baicalin, and the effect of atractylodes rhizome oil was the best.

CONCLUSION

Atractylodes rhizome oil is an effective enhancer for percutaneous penetration of baicalin.