Hopman Maria T E, Groothuis Jan T, Flendrie Marcel, Gerrits Karin H L, Houtman Sibrand
Department of Physiology, University Medical Centre Nijmegen, 6500 HB Nijmegen, The Netherlands.
J Appl Physiol (1985). 2002 Dec;93(6):1966-72. doi: 10.1152/japplphysiol.00897.2001.
The purpose of the present study was to determine the effect of a spinal cord injury (SCI) on resting vascular resistance in paralyzed legs in humans. To accomplish this goal, we measured blood pressure and resting flow above and below the lesion (by using venous occlusion plethysmography) in 11 patients with SCI and in 10 healthy controls (C). Relative vascular resistance was calculated as mean arterial pressure in millimeters of mercury divided by the arterial blood flow in milliliters per minute per 100 milliliters of tissue. Arterial blood flow in the sympathetically deprived and paralyzed legs of SCI was significantly lower than leg blood flow in C. Because mean arterial pressure showed no differences between both groups, leg vascular resistance in SCI was significantly higher than in C. Within the SCI group, arterial blood flow was significantly higher and vascular resistance significantly lower in the arms than in the legs. To distinguish between the effect of loss of central neural control vs. deconditioning, a group of nine SCI patients was trained for 6 wk and showed a 30% increase in leg blood flow with unchanged blood pressure levels, indicating a marked reduction in vascular resistance. In conclusion, vascular resistance is increased in the paralyzed legs of individuals with SCI and is reversible by training.
本研究的目的是确定脊髓损伤（SCI）对人类瘫痪腿部静息血管阻力的影响。为实现这一目标，我们测量了11例脊髓损伤患者和10名健康对照者（C）损伤部位上下的血压和静息血流（采用静脉阻塞体积描记法）。相对血管阻力的计算方法是，以毫米汞柱为单位的平均动脉压除以每100毫升组织每分钟以毫升为单位的动脉血流量。脊髓损伤患者交感神经缺失且瘫痪的腿部的动脉血流量显著低于健康对照者腿部的血流量。由于两组的平均动脉压无差异，脊髓损伤患者腿部的血管阻力显著高于健康对照者。在脊髓损伤组内，手臂的动脉血流量显著高于腿部，血管阻力显著低于腿部。为区分中枢神经控制丧失与失健的影响，一组9例脊髓损伤患者接受了6周的训练，结果显示腿部血流量增加了30%，而血压水平未变，这表明血管阻力显著降低。总之，脊髓损伤患者瘫痪腿部的血管阻力增加，且通过训练可逆转。
