Ye Z, Gao D L, Qin Q, Ray R M, Thomas D B
Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, PO Box 19024,MP 474, Seattle, Washington, WA 98109-1024, USA.
Br J Cancer. 2002 Oct 21;87(9):977-81. doi: 10.1038/sj.bjc.6600603.
The possible influence of induced abortion on breast cancer risk was assessed in a cohort of 267 040 women enrolled in a randomised trial of breast self-examination in Shanghai, China. Based on answers to a baseline questionnaire, subsequent breast cancer risk was not significantly associated with ever having an induced abortion. After adjustment for potential confounders, the relative risk estimate was 1.06 (95% C.I.: 0.91, 1.25), and there was no trend in risk with number of abortions. Analysis of data from more detailed interviews of 652 cases and 694 controls from the cohort yielded similar results. There was also no overall increase in risk in women with induced abortion after first birth. Few women had undergone an abortion after 13 weeks gestation or before their first child. Although increases in risk were observed in such women, they were not statistically significant and could have been due to recall bias. Abortions as they have been performed in China are not an important cause of breast cancer.
在中国上海一项乳房自我检查随机试验中，对267040名女性队列进行研究，评估人工流产对乳腺癌风险的可能影响。根据基线调查问卷的回答，后续乳腺癌风险与曾进行人工流产无显著关联。在对潜在混杂因素进行调整后，相对风险估计值为1.06（95%置信区间：0.91，1.25），且风险未随流产次数呈现出趋势变化。对该队列中652例病例和694例对照进行更详细访谈的数据进行分析，得出了类似结果。首次生育后进行人工流产的女性总体风险也未增加。很少有女性在妊娠13周后或生育第一个孩子之前进行流产。尽管在这些女性中观察到风险增加，但无统计学意义，可能是由于回忆偏倚所致。在中国进行的人工流产并非乳腺癌的重要病因。
