Horváth Krisztina, Kövér Ferenc, Kovács Norbert, Kállai János, Nagy Ferenc
Pécsi Tudományegyetem, Altalános Orvostudományi Kar, Neurológia Klinika.
Orv Hetil. 2002 Sep 15;143(37):2145-51.
Volumetric analysis of brain magnetic resonance images (MRI) measures structural changes associated with neurological and neuropsychiatric disorders. In recent years several studies have shown the utility of the volumetric measurement of the medial temporal lobe structures, especially the amygdala and the hippocampus in temporal lobe epilepsy, memory disorders, Alzheimer disease and schizophrenia.
The purpose of this study was to measure and establish our normal values of the hippocampus and amygdala volumes.
All studies were performed using a 1.0 T Siemens unit with FISP 3D sequence. One millimeter, contiguous coronal scans of 40 healthy volunteers aged 19-26 years were obtained. The regions of interest were outlined using a mouse driven cursor. To determine the anatomic boundaries of the hippocampus and the amygdala the authors followed a generally accepted protocol previously described by C. Watson.
The mean right and left hippocampal volumes were 2.12 cm3 (SD = 0.31) and 2.07 cm3 (SD = 0.3) and the mean right and left amygdaloid volume were 1.19 cm3 (SD = 0.19) and 1.2 cm3 (SD = 0.2) respectively. The mean asymmetry between the right and left hippocampus and amygdala was 3.17% and 3.48%, respectively. The inter-observer reliability range (alpha) was between 0.97 and 0.77. Subregional analysis of hippocampus was calculated as well.
Normal volumetric data measured in our study fell in the midrange of the values in the literature. The volumetric analysis of the hippocampal subregions may allow assessment of providing more sensitive determination of the atrophic area, which may be important in epileptic disorders.
脑磁共振成像（MRI）的容积分析可测量与神经和神经精神疾病相关的结构变化。近年来，多项研究表明内侧颞叶结构的容积测量具有实用性，尤其是杏仁核和海马体在颞叶癫痫、记忆障碍、阿尔茨海默病和精神分裂症中的应用。
本研究的目的是测量并确立我们自己的海马体和杏仁核体积的正常值。
所有研究均使用配备FISP 3D序列的1.0 T西门子设备进行。对40名年龄在19至26岁之间的健康志愿者进行了1毫米连续冠状扫描。使用鼠标驱动的光标勾勒出感兴趣区域。为了确定海马体和杏仁核的解剖边界，作者遵循了C. Watson先前描述的普遍接受的方案。
右侧和左侧海马体的平均体积分别为2.12 cm³（标准差=0.31）和2.07 cm³（标准差=0.3），右侧和左侧杏仁核的平均体积分别为1.19 cm³（标准差=0.19）和1.2 cm³（标准差=0.2）。右侧和左侧海马体及杏仁核之间的平均不对称率分别为3.17%和3.48%。观察者间可靠性范围（α）在0.97至0.77之间。还对海马体进行了亚区域分析。
我们研究中测量的正常容积数据处于文献报道值的中间范围。海马体亚区域的容积分析可能有助于更敏感地评估萎缩区域，这在癫痫疾病中可能很重要。
