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[小儿气管支气管软化症:临床经验]

[Tracheobronchomalacia in pediatric patients: clinical experience].

作者信息

Castillo Andrés, Smith Jeany, Figueroa Valeria, Bertrand Pablo, Sánchez Ignacio

机构信息

Unidad de Cuidados Intensivos Pediátricos, Hospital Clínico Pontiflicia Universidad Católica de Chile.

出版信息

Rev Med Chil. 2002 Sep;130(9):1014-20.

Abstract

BACKGROUND

Tracheobronchomalacia is characterized by a deficiency in the cartilaginous support of the trachea and bronchi and hypotony in the myoelastic elements, that lead to different levels of airway obstruction.

AIM

To report our experience in the treatment of traqueobronchomalacia.

MATERIAL AND METHODS

Retrospective review of 24 patients with tracheomalacia of different levels (3 tracheobronchomalacia, 3 laryngotracheomalacia) and 8 patients with bronchomalacia.

RESULTS

The age at diagnosis ranged from 9 days to 9 years. Clinical presentation was recurrent wheezing in 19 patients, stridor in 6 and atelectasis in 4. The associated factors were neurological impairment in 8, congenital heart disease in 10 and prolonged mechanical ventilation in 4. The diagnosis was done by flexible bronchoscopy in all patients, using sedation and allowing spontaneous breathing. At the moment of diagnosis, treatment consisted in oxygen supply in 14 patients, physiotherapy in 21, beta 2 adrenergic agonists in 27, racemic epinephrine in 8, mechanical ventilation in 12, ipratropium bromide in 5 and inhaled steroids in 13. After diagnosis, 24 patients received bronchodilator therapy with ipratropium bromide, 15 received racemic epinephrine and 22 received inhaled steroids. In 21, beta 2 adrenergic agonists were discontinued. Thirteen patients required ventilation support and home oxygen. Twenty two patients showed a satisfactory clinical evolution and 6 patients died.

CONCLUSIONS

The clinical presentation of tracheobronchomalacia is varied and diagnosis is done by flexible bronchoscopy. Treatment will depend on the severity of the disease, but beta 2 adrenergic agonists should be excluded.

摘要

背景

气管支气管软化症的特征是气管和支气管软骨支撑不足以及肌弹性成分张力减退,导致不同程度的气道阻塞。

目的

报告我们治疗气管支气管软化症的经验。

材料与方法

回顾性分析24例不同程度气管软化症患者(3例气管支气管软化症、3例喉气管软化症)及8例支气管软化症患者。

结果

诊断时年龄从9天至9岁不等。临床表现为19例反复喘息、6例喘鸣和4例肺不张。相关因素包括8例神经功能障碍、10例先天性心脏病和4例机械通气时间延长。所有患者均通过柔性支气管镜检查确诊,检查时使用镇静剂并允许自主呼吸。诊断时,14例患者接受吸氧治疗,21例接受物理治疗,27例使用β2肾上腺素能激动剂,8例使用消旋肾上腺素,12例接受机械通气,5例使用异丙托溴铵,13例使用吸入性糖皮质激素。诊断后,24例患者接受异丙托溴铵支气管扩张治疗,15例接受消旋肾上腺素治疗,22例接受吸入性糖皮质激素治疗。21例患者停用β2肾上腺素能激动剂。13例患者需要通气支持和家庭吸氧。22例患者临床进展良好,6例患者死亡。

结论

气管支气管软化症临床表现多样,通过柔性支气管镜检查确诊。治疗取决于疾病严重程度,但应停用β2肾上腺素能激动剂。

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