Drug Ther Bull. 2002 Oct;40(10):73-5.
Conventional treatment of atopic dermatitis includes the regular, frequent use of emollients, and intermittent application of topical corticosteroids to control acute 'flares'. [symbol: see text] Tacrolimus (pronounced ta-kro-li-mus), which is available for systemic use for the prevention of organ rejection following allogenic liver and kidney transplantation, is now formulated as an immunosuppressant ointment (Protopic-Fujisawa). This is licensed for use in adults and children aged 2 years and over with moderate to severe atopic dermatitis inadequately responsive to conventional therapy. Promotion states that, in these groups, tacrolimus is "at least as effective as topical steroids" and "without the potential side effects of conventional therapy". Here we consider the place of tacrolimus ointment in the management of atopic dermatitis.
特应性皮炎的传统治疗方法包括定期、频繁使用润肤剂，以及间歇性外用糖皮质激素以控制急性“发作”。[符号：见正文] 他克莫司（发音为ta-kro-li-mus）可用于全身用药以预防同种异体肝、肾移植后的器官排斥反应，现在已制成免疫抑制剂软膏（普特彼 - 藤泽）。该药已获许可用于2岁及以上患有中度至重度特应性皮炎且对传统疗法反应不佳的成人和儿童。宣传资料称，在这些人群中，他克莫司“至少与外用类固醇一样有效”，且“没有传统疗法的潜在副作用”。在此，我们探讨他克莫司软膏在特应性皮炎治疗中的地位。
