Groenendaal F, Rademaker C M A, Toet M C, de Vries L S
Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center, Utrecht, The Netherlands.
Acta Paediatr. 2002;91(10):1073-7. doi: 10.1080/080352502760311575.
In this study it is hypothesized that magnesium sulphate in asphyxiated full-term neonates could lead to a gradual improvement in background pattern of the amplitude integrated EEG (aEEG), an early marker of hypoxic-ischaemic brain injury. In a double-blind, randomized, controlled pilot study of 22 asphyxiated full-term neonates 8 received magnesium sulphate, reaching serum Mg2+ levels of 2.5 mmol/L. Magnesium sulphate had no immediate effect on aEEG-patterns. At 12 h of age, aEEG was more depressed compared with aEEG at 3 h in 6 of the 8 magnesium-treated neonates, and in 3 of the 14 placebo-treated neonates (Mg2+ vs placebo: p < 0.05, Mann-Whitney). No further significant changes in aEEG were seen between 12 and 24 h. Outcome was unfavourable in 4 of the 8 magnesium-treated neonates, and in 8 of the 14 placebo-treated neonates.
Magnesium sulphate did not have a positive effect on aEEG patterns in this small group of asphyxiated term neonates.
在本研究中，假设硫酸镁对足月窒息新生儿的振幅整合脑电图（aEEG）背景模式（缺氧缺血性脑损伤的早期标志物）可能会有逐渐改善的作用。在一项针对22名足月窒息新生儿的双盲、随机、对照试验性研究中，8名接受硫酸镁治疗，血清镁离子（Mg2+）水平达到2.5 mmol/L。硫酸镁对aEEG模式无即刻影响。在8名接受镁治疗的新生儿中，6名在12小时龄时的aEEG比3小时龄时更受抑制，在14名接受安慰剂治疗的新生儿中，3名出现这种情况（镁离子治疗组与安慰剂组比较：p<0.05，曼-惠特尼检验）。在12至24小时之间，aEEG未见进一步显著变化。8名接受镁治疗的新生儿中有4名预后不良，14名接受安慰剂治疗的新生儿中有8名预后不良。
在这一小群足月窒息新生儿中，硫酸镁对aEEG模式无积极作用。
