（+）-肾上腺酮的微生物转化

Microbial transformation of (+)-adrenosterone.

作者信息

Musharraf S Ghulam, Choudhary M Iqbal, Sultan Sadia

机构信息

H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Pakistan.

出版信息

Nat Prod Lett. 2002 Oct;16(5):345-9. doi: 10.1080/10575630290033105.

DOI:10.1080/10575630290033105

PMID:12434991

Abstract

The microbial transformation of (+)-adrenosterone (1) by Cephalosporium aphidicola afforded three metabolites identified as androsta-1,4-diene-3,11,17-trione (2), 17beta-hydroxyandrost-4-ene-3,11-dione (3) and 17beta-hydroxyandrosta-1,4-diene-3,11-dione (4). The fermentation of 1 with Fusarium lini also produced metabolites 2 and 4, while the fermentation with Trichothecium roseum afforded metabolite 3. The structures of transformed products were determined by spectroscopic methods.

摘要

蚜虫头孢霉对（+）-肾上腺酮（1）进行微生物转化得到了三种代谢产物，分别鉴定为雄甾-1,4-二烯-3,11,17-三酮（2）、17β-羟基雄甾-4-烯-3,11-二酮（3）和17β-羟基雄甾-1,4-二烯-3,11-二酮（4）。亚麻镰刀菌对1的发酵也产生了代谢产物2和4，而粉红单端孢霉的发酵产生了代谢产物3。通过光谱方法确定了转化产物的结构。