Naumann Ralph, Beuthien-Baumann Bettina, Fischer Rainer, Kittner Thomas, Bredow Jan, Kropp Joachim, Ockert Detlef, Ehninger Gerhard
Department of Internal Medicine I, University Hospital Carl Gustav Carus at the Dresden University of Technology, Dresden, Germany.
Clin Lymphoma. 2002 Sep;3(2):121-4. doi: 10.3816/clm.2002.n.019.
Positron emission tomography (PET) with [18F]fluorodeoxyglucose [18F]FDG has evolved as a method of increasingly clinical importance in the management of patients with malignant lymphoma. However, inflammatory lesions also accumulate [18F]FDG and may cause difficulties with interpretation. This report deals with 2 patients with simultaneous occurrence of Hodgkin's lymphoma and eosinophilic granuloma, a rare but known coincidence of diseases. In the first case, Hodgkin's disease could not be differentiated from eosinophilic granuloma. Positron emission tomography showed increased [18F]FDG uptake both in lymphoma manifestations and in the granuloma. In the second case with proven Hodgkin's disease, post-treatment examination showed a positive PET lesion in the mediastinal residual mass, which was interpreted as viable lymphoma. However, histologic examination revealed that it was an eosinophilic granuloma.
正电子发射断层扫描（PET）联合[18F]氟脱氧葡萄糖（[18F]FDG）已发展成为一种在恶性淋巴瘤患者管理中临床重要性日益增加的方法。然而，炎症性病变也会摄取[18F]FDG，可能导致解读困难。本报告涉及2例同时发生霍奇金淋巴瘤和嗜酸性肉芽肿的患者，这是一种罕见但已知的疾病巧合。在第一例中，霍奇金病无法与嗜酸性肉芽肿区分开来。正电子发射断层扫描显示淋巴瘤表现和肉芽肿中[18F]FDG摄取均增加。在第二例经证实的霍奇金病患者中，治疗后检查显示纵隔残留肿块处PET病变呈阳性，被解释为存活的淋巴瘤。然而，组织学检查显示它是一个嗜酸性肉芽肿。
