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Antimalarial chemotherapeutic peroxides: artemisinin, yingzhaosu A and related compounds.

作者信息

Borstnik Kristina, Paik Ik-hyeon, Shapiro Theresa A, Posner Gary H

机构信息

Department of Chemistry, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218-2685, USA.

出版信息

Int J Parasitol. 2002 Dec 4;32(13):1661-7. doi: 10.1016/s0020-7519(02)00195-9.

DOI:10.1016/s0020-7519(02)00195-9
PMID:12435451
Abstract

Mechanism-based rational design and gram-scale chemical synthesis have produced some new trioxane and endoperoxide antimalarial drug candidates that are efficacious and safe. This review summarises recent achievements in this area of peroxide drug development for malaria chemotherapy.

摘要

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