Alkadi Hussein O, Noman Majed A, Al-Thobhani Abdulla K, Al-Mekhlafi Fuad S, Raja'a Yahia A
Department of Pharmacology, Sana'a University, Sana'a, Yemen.
Saudi Med J. 2002 Oct;23(10):1195-8.
To evaluate the effect of Khat-induced myocardial infarction (MI) in Yemen.
One hundred and twenty patients with MI, admitted to Al-Thawra Hospital, Sana'a City, Yemen, during the year 2001 and 120 volunteer controls were collected for this study. On the other hand, we used 48 adult male rabbits for this study and divided it into 8 groups. Each group was consist of 6 animals; group I was used as normal control, group II was given adrenaline 60 g/kg intravenous infusion, group III and IV were given Khat 1g/kg once daily for 2 months, group V and VI were given Khat 1g/kg 3 times daily for 2 months, group VII and VIII were given Khat extract equivalent to 1g/kg intravenous infusion, 4 hours after the last dose of Khat and adrenaline 60 g/kg intravenous infusion was given to groups IV, VI and VIII. The animals were killed by decapitation. Blood samples were collected from each rabbit for determination of their creatinine kinase-iso enzyme (CK-MB) lactate dehydrogenase (LDH) and serum glutamic-oxaloacetic transaminase enzymes. Also, hearts were dissected out rapidly for histopathological study.
Seventy-nine percent of patients with MI were Khat chewers and only 20.8% were non-Khat chewers. Experimental study shows that Khat in a dose of 1g/kg 3 times a day for 2 months, Khat extract equivalent to 1g/kg intravenous infusion alone and in combination with adrenaline 60 g/kg intravenous infusion significantly increased cardiac enzymes (CK-MB, aspartate transaminase, LDH), also, the histopathological study for the same groups revealed multiple areas of infarction.
The present study has demonstrated that Khat chewing may be considered as a risk factor for the occurrence of MI especially in persons who are susceptible to the disease. It is therefore, recommended that Khat chewing should be avoided in persons who have any cardiovascular problems.
评估巧茶致也门心肌梗死（MI）的作用。
收集2001年期间入住也门萨那市革命医院的120例心肌梗死患者以及120名志愿者作为对照进行本研究。另一方面，本研究选用48只成年雄性兔子，将其分为8组。每组6只动物；I组用作正常对照，II组静脉注射肾上腺素60μg/kg，III组和IV组每天给予巧茶1g/kg，持续2个月，V组和VI组每天给予巧茶1g/kg，分3次给药，持续2个月，VII组和VIII组静脉注射相当于1g/kg巧茶的提取物，IV组、VI组和VIII组在最后一剂巧茶和静脉注射60μg/kg肾上腺素4小时后给药。通过断头处死动物。采集每只兔子的血样以测定其肌酸激酶同工酶（CK-MB）、乳酸脱氢酶（LDH）和血清谷草转氨酶。此外，迅速取出心脏进行组织病理学研究。
79%的心肌梗死患者嚼食巧茶，只有20.8%的患者不嚼食巧茶。实验研究表明，每天3次给予1g/kg巧茶，持续2个月，单独静脉注射相当于1g/kg巧茶的提取物以及与静脉注射60μg/kg肾上腺素联合使用均显著增加心脏酶（CK-MB、天冬氨酸转氨酶、LDH），同样，对相同组别的组织病理学研究显示存在多个梗死区域。
本研究表明，嚼食巧茶可能被视为心肌梗死发生的一个危险因素，尤其是在易患该疾病的人群中。因此，建议有任何心血管问题的人应避免嚼食巧茶。
