Cikrt M, Tichý M, Holusa R
Arch Toxicol. 1975 Nov 20;34(3):227-36. doi: 10.1007/BF00353285.
In rats the effect of a chronic administration of CCl4 on the excretion and disstribution of 64Cu, 65Zn, and 203Hg was investigated. The bilary excretion of these metals was studied with particular attention. It was found that total excretion of 64Cu, 65Zn, or 203Hg from the organism did not change significantly in comparison with the control groupp, but the ratio of individual excretion pathways did change. The course of excretion curves regarding the bile in exposed animals is prolonged. The histologic examination of the livers revealed a large interindividual variability in the response of the liver tissue to the same CCl4 exposure. Differences in distribution in the kidneys and livers in exposed and control animals was also found.
在大鼠中，研究了长期给予四氯化碳对64Cu、65Zn和203Hg排泄及分布的影响。特别关注了这些金属的胆汁排泄情况。结果发现，与对照组相比，机体对64Cu、65Zn或203Hg的总排泄量没有显著变化，但个体排泄途径的比例发生了改变。暴露动物胆汁排泄曲线的过程延长。肝脏的组织学检查显示，肝组织对相同四氯化碳暴露的反应存在很大的个体差异。还发现了暴露动物与对照动物在肾脏和肝脏中的分布差异。
