Büsche G, Nolte M, Schlue J, Kreft A, Kreipe H H
Institut für Pathologie, Medizinische Hochschule Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.
Pathologe. 2002 Nov;23(6):419-25. doi: 10.1007/s00292-002-0583-8. Epub 2002 Oct 18.
The diagnosis of chronic eosinophilic leukemia (CEL) is based on the evidence of an autonomous, clonal proliferation of eosinophilic precursors and the exclusion of other myeloid neoplasms with eosinophilia. Histopathological evaluations of bone marrow are rare, and reliable data on the frequency of CEL do not yet exist. A total of 100 cases characterized by eosinophilia >/=1.5x10(9)/l blood for more than 6 months were evaluated. In 87 cases, the eosinophilia turned out to be secondary and a reactive genesis was likely, but not proven in 3 further cases. Idiopathic hypereosinophilic syndrome was diagnosed in three cases. The diagnosis CEL was considered in four out of a total of seven cases with a myeloid neoplasia and all four disorders showed an abnormal karyotype. However, only one of them could be classified as CEL. We conclude that CEL is a rare disease concerning only a minority of cases with chronic eosinophilia.
慢性嗜酸性粒细胞白血病（CEL）的诊断基于嗜酸性粒细胞前体细胞自主克隆增殖的证据以及排除其他伴有嗜酸性粒细胞增多的髓系肿瘤。骨髓的组织病理学评估很少见，目前尚无关于CEL发病率的可靠数据。对100例血液中嗜酸性粒细胞≥1.5×10⁹/L持续超过6个月的病例进行了评估。87例中，嗜酸性粒细胞增多为继发性，另外3例可能为反应性，但未得到证实。3例诊断为特发性高嗜酸性粒细胞综合征。在总共7例髓系肿瘤病例中，有4例考虑诊断为CEL，所有4种疾病均显示核型异常。然而，其中只有1例可归类为CEL。我们得出结论，CEL是一种罕见疾病，仅涉及少数慢性嗜酸性粒细胞增多的病例。
