[Action of fomocaine on heart and circulation (author's transl)].

Fomocaine shows antiarrhythmic properties. It prolongs the periods of the ECG (anaesthetized cats) and the functional refractory period (left atria of guinea-pigs, electrically driven). Effects on these parameters are qualitatively the same as with quinidine. Quantitatively fomocaine prolongs the functional refractory period in the same, the PQ-interval to a greater extent than does quinidine. In contrast quinidine has a greater effect on QRS- and QT-interval. Up to higher doses fomocaine's efficacy on contractility (dp/dtmax) and blood pressure is opposite to quinidine because they are increased by fomocaine and decreased by quinidine. The lack of toxic ECG-signs prior to lethal dosis makes fomocaine dangerous in overdosage.