Jauch R, Hankwitz R, Maass D, Wollmann R
Arzneimittelforschung. 1975;25(12):1954-8.
The fate of 14C-labelled bromhexine (Bisolvon¿) in man following intravenous and oral administration was studied by investigation of the blood and plasma levels and the excretion profiles. Slight variations observed between the two administration routes are explained by the somewhat different distribution patterns resulting from the different "first path" after oral application (liver) and intravenous injection (tissues).
通过对血液和血浆水平以及排泄情况的研究，探讨了静脉注射和口服给药后，14C标记的溴己新（必嗽平）在人体内的代谢情况。两种给药途径观察到的细微差异，可由口服（肝脏）和静脉注射（组织）后不同的“首过效应”导致的分布模式差异来解释。
