[金霉素产生菌金色链霉菌的自发变异和诱发变异]
[Spontaneous and induced variability of Streptomyces aureofaciens--chlortetracycline producer].
作者信息
Stryzhkova H M, Kopeĭko O P, Lavrinchuk V Ia, Bambura O I, Matseliukh B P
机构信息
Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, 154 Zabolotny St., Kyiv, 03143, Ukraine.
出版信息
Mikrobiol Z. 2002 Jul-Aug;64(4):19-23.
Spontaneous and induced variability of Streptomyces aureofaciens strain T[symbol: see text] 633 [symbol: see text] and its variants has been investigated. Correlative relation between the antibiotic formation and colonies morphology was observed. Combined effect of nitrosoguanidine and UV-beams resulted in the obtaining of 27 variants which exceeded activity of strain T[symbol: see text] 633 [symbol: see text] by 30-35% and were stable as to antibiotic biosynthesis during 7-10 generations.
对金色链霉菌菌株T[符号：见原文]633[符号：见原文]及其变体的自发和诱导变异性进行了研究。观察到抗生素形成与菌落形态之间的相关关系。亚硝基胍和紫外线的联合作用导致获得了27个变体，其活性比菌株T[符号：见原文]633[符号：见原文]高出30-35%，并且在7-10代期间抗生素生物合成方面是稳定的。
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