双核[Cu(TSA)₂py]₂配合物的超氧化物歧化酶活性及电化学研究

Superoxide dismutase activity and electrochemical study of the binuclear [Cu(TSA)2py]2 complex.

作者信息

Parajón Costa Beatriz Susana, Tótaro Roxana Maria, Ferrer Evelina Gloria, Williams Patricia Ana Maria

机构信息

Centro de Química Inorgánica, Facultad de Ciencias Exactas, UNLP, La Plata, Argentina.

出版信息

J Trace Elem Med Biol. 2002;16(3):183-6. doi: 10.1016/s0946-672x(02)80023-2.

DOI:10.1016/s0946-672x(02)80023-2

PMID:12437156

Abstract

The superoxide dismutase-mimetic activity and the electrochemical behavior of the binuclear complex [Cu(TSA)2py]2 is reported. The complex exhibits a marked SOD activity in the nitroblue tetrazolium assay. Its redox response is in agrement with two copper atoms partially coupled through the carboxylate moieties. The electrode reactions lie in the range of the superoxide/peroxide and oxygen/superoxide couples. This fact is indicative that this complex can act as catalyst for the SOD reaction.

摘要

报道了双核配合物[Cu(TSA)₂py]₂的超氧化物歧化酶模拟活性和电化学行为。该配合物在硝基蓝四唑测定中表现出显著的超氧化物歧化酶活性。其氧化还原响应与通过羧酸盐部分部分耦合的两个铜原子一致。电极反应处于超氧化物/过氧化物和氧气/超氧化物电对的范围内。这一事实表明该配合物可作为超氧化物歧化酶反应的催化剂。