Kalsi J S, Cellek S, Muneer A, Kell P D, Ralph D J, Minhas S
The Institute of Urology and Nephrology, University College London, 48 Riding House Street, London, W1P 7NN, UK.
Expert Opin Pharmacother. 2002 Nov;3(11):1613-29. doi: 10.1517/14656566.3.11.1613.
Erectile dysfunction (ED) is defined as the inability to achieve and maintain a penile erection adequate for satisfactory sexual intercourse. It is a significant male health problem of global dimensions affecting approximately 150 million men worldwide. A broad range of options are currently available for the management of ED. They include oral agents (phosphodiesterase 5 inhibitors, dopamine agonists and alpha-receptor blocking drugs), intracavernosal injection (papaverine, phentolamine, prostaglandin E1, vasoactive intestinal peptide), transurethral vasoactive agents (prostaglandin E1), vacuum erection devices, vascular surgery and penile prostheses. Here we review the physiology of penile erection and the currently available oral preparations. In addition, novel therapeutic strategies to improve erectile function are discussed.
勃起功能障碍（ED）的定义是无法实现并维持足以进行满意性交的阴茎勃起。它是一个具有全球影响的重大男性健康问题，全球约有1.5亿男性受其影响。目前有多种治疗勃起功能障碍的方法可供选择。它们包括口服药物（磷酸二酯酶5抑制剂、多巴胺激动剂和α受体阻断药物）、海绵体内注射（罂粟碱、酚妥拉明、前列腺素E1、血管活性肠肽）、经尿道血管活性药物（前列腺素E1）、真空勃起装置、血管手术和阴茎假体。在此，我们综述阴茎勃起的生理学以及目前可用的口服制剂。此外，还讨论了改善勃起功能的新治疗策略。
