用α-2b干扰素和利巴韦林治疗急性丙型肝炎病毒感染：病例报告及文献综述
Treatment of acute hepatitis C virus infection with interferon-alpha 2b and ribavirin: case report and review of the literature.
作者信息
Leblebicioglu Hakan, Bayirli Derya, Esen Saban, Sunbul Mustafa, Eroglu Cafer
机构信息
Department of Infectious Diseases and Clinical Microbiology, Ondokuz Mayis University Medical School, Samsun, Turkey.
出版信息
Ann Clin Microbiol Antimicrob. 2002 Oct 14;1:3. doi: 10.1186/1476-0711-1-3.
UNLABELLED
Hepatitis C virus (HCV) infection becomes chronic in about 85 % of individuals as demonstrated by the persistence of HCV. It is necessary to treat acute hepatitis C infection. Interferon-alpha is generally used for the treatment of acute HCV infection.
CASE PRESENTATION
A 55-year-old woman with a history of fatigue and icter was diagnosed as acute hepatitis C virus infection. She was treated with interferon-alpha 2b 3 million unite sc three times in a week and ribavirin 1000 mg daily for 6 months. Within 2 weeks of therapy, the alanine aminotransferase (ALT) had became normal. At the end of the 3 months of therapy, HCV RNA was negative and remained negative 6 months after the end of interferon treatment (sustained response).
CONCLUSION
This report suggests that interferon-alpha 2b and ribavirin may have a role in treatment of acute hepatitis C virus infection.
未标注
丙型肝炎病毒（HCV）感染在约85%的个体中会转为慢性，这可通过HCV的持续存在得到证明。治疗急性丙型肝炎感染是必要的。α干扰素通常用于治疗急性HCV感染。
病例报告
一名有疲劳和黄疸病史的55岁女性被诊断为急性丙型肝炎病毒感染。她接受了α干扰素2b 300万单位皮下注射，每周3次，以及利巴韦林每日1000毫克的治疗，持续6个月。治疗2周内，丙氨酸氨基转移酶（ALT）恢复正常。治疗3个月末，HCV RNA呈阴性，且在干扰素治疗结束6个月后仍保持阴性（持续应答）。
结论
本报告提示α干扰素2b和利巴韦林可能在急性丙型肝炎病毒感染的治疗中发挥作用。
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