Bryant Darrell L, Free R Benjamin, Thomasy Sara M, Lapinsky David J, Ismail K A, Arason K M, Bergmeier Stephen C, McKay Dennis B
Division of Pharmacology, The Ohio State University, College of Pharmacy, Columbus, Ohio 43210, USA.
Ann N Y Acad Sci. 2002 Oct;971:139-41. doi: 10.1111/j.1749-6632.2002.tb04448.x.
Adrenal secretion and binding studies were performed using ring E analogues of methyllycaconitine to assess structural determinants affecting activity on bovine adrenal alpha3beta4* nicotinic receptors. The most potent analogues are as potent as many inhibitors of adrenal secretion. Our data support the potential use of methyllycaconitine analogues to generate nicotinic receptor subtype-specific compounds.
利用甲基lycaconitine的E环类似物进行了肾上腺分泌和结合研究，以评估影响对牛肾上腺α3β4*烟碱受体活性的结构决定因素。最有效的类似物与许多肾上腺分泌抑制剂一样有效。我们的数据支持使用甲基lycaconitine类似物来生成烟碱受体亚型特异性化合物的可能性。
