Joseph Jan, Niggemann Bernd, Zaenker Kurt S, Entschladen Frank
Institute for Immunology, Witten/Herdecke University, 58448 Witten, Germany.
Cancer Res. 2002 Nov 15;62(22):6467-9.
Gamma-aminobutyric acid (GABA) is the inhibitory neurotransmitter in the brain, also playing a role in diseases like epilepsy. We now show that this inhibitory neurotransmitter can also reduce migratory activity in SW 480 colon carcinoma cells. GABA reduced the norepinephrine-induced migratory activity of these cells within a three-dimensional collagen matrix to spontaneous migration levels, as was analyzed by time-lapse videomicroscopy. This inhibitory effect of GABA was mediated by the serpentine receptor GABA(B) and was intracellularly transduced by a decrease of the cyclic AMP concentration. Cancer cell migration is thus regulated by neurobiological signals, opening new possibilities for pharmacological agonists in cancer therapy.
γ-氨基丁酸（GABA）是大脑中的抑制性神经递质，在癫痫等疾病中也发挥作用。我们现在表明，这种抑制性神经递质还可以降低SW 480结肠癌细胞的迁移活性。通过延时视频显微镜分析，GABA将这些细胞在三维胶原基质中去甲肾上腺素诱导的迁移活性降低至自发迁移水平。GABA的这种抑制作用由蛇形受体GABA(B)介导，并通过细胞内环磷酸腺苷浓度的降低在细胞内传导。癌细胞迁移因此受到神经生物学信号的调节，为癌症治疗中的药理学激动剂开辟了新的可能性。
