Gomez Henry F, Ochoa Theresa J, Herrera-Insua Irene, Carlin Lily G, Cleary Thomas G
Division of Infectious Diseases, Department of Pediatrics, University of Texas-Houston Medical School, 77030, USA.
Infect Immun. 2002 Dec;70(12):7050-3. doi: 10.1128/IAI.70.12.7050-7053.2002.
Shigella species cause bacillary dysentery in humans by invasion, intracellular multiplication, spread to adjacent cells, and induction of brisk inflammatory responses in the intestinal epithelium. In vitro data suggest that lactoferrin, a glycoprotein present in human mucosal secretions, has a role in protection from bacterial enteric infections. We sought to determine the activity of lactoferrin in vivo, using the concentration present in human colostrum, to investigate its effect on the development of clinical and pathological evidence of inflammation in a rabbit model of enteritis. Lactoferrin protected rabbits infected with Shigella flexneri from developing inflammatory intestinal disease. Typical histological changes in ill animals included villous blunting with sloughing of epithelial cells, submucosal edema, infiltration of leukocytes, venous congestion, and hemorrhage. Lactoferrin at a concentration normally found in human colostrum blocks development of S. flexneri-induced inflammatory enteritis.
志贺氏菌属通过侵入、细胞内增殖、扩散至相邻细胞以及在肠道上皮细胞中引发强烈炎症反应，从而导致人类患细菌性痢疾。体外实验数据表明，乳铁蛋白（一种存在于人类黏膜分泌物中的糖蛋白）在预防细菌性肠道感染方面发挥着作用。我们试图利用人初乳中的乳铁蛋白浓度来确定其在体内的活性，以研究其对兔肠炎模型中炎症的临床和病理证据发展的影响。乳铁蛋白可保护感染福氏志贺菌的兔子不发生炎症性肠道疾病。患病动物的典型组织学变化包括绒毛变钝伴上皮细胞脱落、黏膜下水肿、白细胞浸润、静脉淤血和出血。人初乳中正常浓度的乳铁蛋白可阻止福氏志贺菌诱导的炎症性肠炎的发展。
