Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease.
作者信息
Selkoe Dennis J
机构信息
Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA.
出版信息
J Clin Invest. 2002 Nov;110(10):1375-81. doi: 10.1172/JCI16783.
Abstract
摘要
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本文引用的文献
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Presenilins are not required for A beta 42 production in the early secretory pathway.早老素对于早期分泌途径中β淀粉样蛋白42的产生并非必需。
Nat Neurosci. 2002 Sep;5(9):849-55. doi: 10.1038/nn898.
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Identification of signal peptide peptidase, a presenilin-type aspartic protease.信号肽肽酶的鉴定，一种早老素型天冬氨酸蛋白酶。
Science. 2002 Jun 21;296(5576):2215-8. doi: 10.1126/science.1070925.
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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo.淀粉样β蛋白的天然分泌寡聚体在体内可有效抑制海马体长期增强效应。
Nature. 2002 Apr 4;416(6880):535-9. doi: 10.1038/416535a.
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Clearing the brain's amyloid cobwebs.清除大脑中的淀粉样蛋白“蜘蛛网”。
Neuron. 2001 Oct 25;32(2):177-80. doi: 10.1016/s0896-6273(01)00475-5.
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The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture.由γ-分泌酶产生的淀粉样前体蛋白（APP）胞质片段迅速降解，但部分分布于培养神经元的细胞核部分。
J Neurochem. 2001 Sep;78(5):1168-78. doi: 10.1046/j.1471-4159.2001.00516.x.
6
The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner.β-淀粉样前体蛋白的细胞内结构域由Fe65稳定，并以类似Notch的方式转运至细胞核。
J Biol Chem. 2001 Oct 26;276(43):40288-92. doi: 10.1074/jbc.C100447200. Epub 2001 Sep 5.
7
Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils.由β淀粉样蛋白42原纤维诱导的P301l tau转基因小鼠中神经原纤维缠结的形成。
Science. 2001 Aug 24;293(5534):1491-5. doi: 10.1126/science.1062097.
8
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.在表达突变型tau蛋白和淀粉样前体蛋白（APP）的转基因小鼠中神经原纤维变性增强。
Science. 2001 Aug 24;293(5534):1487-91. doi: 10.1126/science.1058189.
9
Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch.早老素依赖的γ-分泌酶在与Notch的S3切割相对应的位点对β-淀粉样前体蛋白进行加工。
EMBO Rep. 2001 Sep;2(9):835-41. doi: 10.1093/embo-reports/kve180. Epub 2001 Aug 23.
10
A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60.APP与Fe65及组蛋白乙酰转移酶Tip60形成的转录活性复合物。 （注：原文中“transcriptively”有误，应为“transcriptionally”，译文已按正确内容翻译）
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