Adoptive therapy with CD8(+) T cells: it may get by with a little help from its friends.
作者信息
Ho William Y, Yee Cassian, Greenberg Philip D
机构信息
Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center and the University of Washington, Department of Medicine, Seattle, Washington, USA.
出版信息
J Clin Invest. 2002 Nov;110(10):1415-7. doi: 10.1172/JCI17214.
Abstract
摘要
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J Clin Invest. 2002 Nov;110(10):1493-501. doi: 10.1172/JCI16356.
2
Adoptive T cell therapy using antigen-specific CD8+ T cell clones for the treatment of patients with metastatic melanoma: in vivo persistence, migration, and antitumor effect of transferred T cells.采用抗原特异性CD8 + T细胞克隆的过继性T细胞疗法治疗转移性黑色素瘤患者：转移T细胞的体内持久性、迁移及抗肿瘤作用
Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16168-73. doi: 10.1073/pnas.242600099. Epub 2002 Nov 11.
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Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes.抗肿瘤淋巴细胞克隆性再增殖后患者的癌症消退与自身免疫
Science. 2002 Oct 25;298(5594):850-4. doi: 10.1126/science.1076514. Epub 2002 Sep 19.
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A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory.CD40在CD8⁺T细胞上的表达在CD8⁺T细胞记忆形成中的作用。
Science. 2002 Sep 20;297(5589):2060-3. doi: 10.1126/science.1072615.
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HIV: current opinion in escapology.艾滋病病毒：逃脱术方面的当前观点。 （不过这个内容看起来不太符合常规医学专业文献的逻辑，可能原文有误，正常应该是关于HIV在医学领域的相关内容）
Curr Opin Microbiol. 2002 Aug;5(4):408-13. doi: 10.1016/s1369-5274(02)00339-9.
6
Maintaining the norm: T-cell homeostasis.维持正常状态：T细胞稳态。
Nat Rev Immunol. 2002 Aug;2(8):547-56. doi: 10.1038/nri853.
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Interleukin-12 in anti-tumor immunity and immunotherapy.白细胞介素-12在抗肿瘤免疫及免疫治疗中的作用
Cytokine Growth Factor Rev. 2002 Apr;13(2):155-68. doi: 10.1016/s1359-6101(01)00032-6.
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Enhanced signaling through the IL-2 receptor in CD8+ T cells regulated by antigen recognition results in preferential proliferation and expansion of responding CD8+ T cells rather than promotion of cell death.通过抗原识别调节的CD8+ T细胞中白细胞介素-2受体增强的信号传导导致应答性CD8+ T细胞优先增殖和扩增，而非促进细胞死亡。
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Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB.通过表达T细胞受体、CD28和4-1BB配体的人工抗原呈递细胞进行多克隆和抗原特异性细胞毒性T淋巴细胞的体外扩增。
Nat Biotechnol. 2002 Feb;20(2):143-8. doi: 10.1038/nbt0202-143.
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