Jiang M, Ma Y, Ni X, Cao G, Ji C, Cheng H, Tang R, Xie Y, Mao Y
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, P.R. China.
Cytogenet Genome Res. 2002;97(1-2):68-71. doi: 10.1159/000064058.
Leucine-rich acidic nuclear protein (LANP) is a member of the leucine-rich repeats (LRRs) superfamily. Here we report on a human homologue of LANP, encoded by the gene ANP32E (alias LANPL). The gene was cloned and identified during large-scale sequencing analysis of a human fetal brain cDNA library. The human protein shared 70% amino acid identity with rat LANP. According to bioinformatics analysis, ANP32E is located on chromosome 1q22. RT-PCR analysis indicates that ANP32E was expressed in human peripheral blood leukocytes, colon, small intestine, prostate, thymus, spleen, skeletal muscle, liver and kidney.
富含亮氨酸的酸性核蛋白（LANP）是富含亮氨酸重复序列（LRR）超家族的成员。在此，我们报告由基因ANP32E（别名LANPL）编码的LANP的人类同源物。该基因是在对人类胎儿脑cDNA文库进行大规模测序分析过程中克隆和鉴定的。人类蛋白质与大鼠LANP具有70%的氨基酸同一性。根据生物信息学分析，ANP32E位于1号染色体的1q22。逆转录聚合酶链反应（RT-PCR）分析表明，ANP32E在人类外周血白细胞、结肠、小肠、前列腺、胸腺、脾脏、骨骼肌、肝脏和肾脏中表达。
