Ticca M, Tomassi G
S TA NU. 1975 Jan-Feb;5(1):23-6.
Several studies indicate that in rats changing the rhythm of feeding from nibbling to meal-eating results in hyperlipogenesis and higher body fat deposition. Among the factors influencing this phenomenon, the effects of age and duration of treatment are not yet clear. Male rats of 4, 6, 12 and 18 weeks have been meal-fed (two 1-hour meals per day) for 5, 10, 20 and 30 days. Pair-fed Nibblers were used as controls. Adipocyte diameters and number from epididymal adipose tissues were determined, and lipogenesis measured my glucose-U-14-C incorporation into lipids. The results show that cellularity, glucose-U-14-C incorporation into adipocyte lipids and CO2 and body fat deposition are not affected by short-term meal-eating treatment in growing animals. In the adult rats, only after 30 days do the parameters studied show significant higher values in the meal-eating animals. The results are discussed in view of the possible interrelationships among the different factors influencing animal response to modifications in feeding frequency.
多项研究表明，在大鼠中，将进食节奏从少食多餐改为一日多餐会导致脂肪生成增加和更高的体脂沉积。在影响这一现象的因素中，年龄和治疗持续时间的影响尚不清楚。对4周、6周、12周和18周的雄性大鼠进行一日多餐喂养（每天两顿1小时的餐食），持续5天、10天、20天和30天。以成对喂养的少食多餐大鼠作为对照。测定附睾脂肪组织中的脂肪细胞直径和数量，并通过葡萄糖-U-14-C掺入脂质来测量脂肪生成。结果表明，在生长中的动物中，短期一日多餐喂养处理不会影响细胞数量、葡萄糖-U-14-C掺入脂肪细胞脂质以及二氧化碳和体脂沉积。在成年大鼠中，只有在30天后，所研究的参数才在一日多餐喂养的动物中显示出显著更高的值。鉴于影响动物对进食频率改变反应的不同因素之间可能存在的相互关系，对结果进行了讨论。
