Rogozea R, Florea-Ciocoiu V
Acta Neurol Latinoam. 1975;21(1-4):40-52.
The electrographic study performed on 106 patients with temporal lobe epilepsy and 31 normal subjects showed marked interictal cerebral reactivity disturbances in this form of epilepsy. These disturbances, estimated by testing the orienting reflex and its habituation, were expressed, as a rule, by intensification of somatic, autonomic and electroencephalographic components of the reaction, increase in their resistance to habituation and change in the sequence in which they become habituated. The severity of reactivity disturbances depended on the localization of electroencephalographic focus, clinical form of seizures and characteristics of interictal electroencephalographic abnormalities. The most marked reactivity disturbances were noted in patients in whom the interictal foci were bitemporal, anterior or predominantly anterior (particularly left), accompanied specially by generalized or generalized + partial seizures or by interictal graphoelements of the irritative type. The reactivity disturbances were less severe in epileptics in whom the interictal foci were unitemporal (particularly right), middle, predominantly middle, posterior or associated to partial seizures. In a few patients in whom the interictal bioelectrical activity reflected a nervous hypoexcitability, the reactivity disturbances assumed the appearance of hyporeactivity. The different intensities of reactivity alterations in temporal lobe epilepsy should be related to the different capacity of the epileptogenic lesions to determine interictal changes in diffuse excitability. This capacity depends on he structures involved by the epileptic discharges, which by their morpho-functional particularities, can influence the cerebral excitability.
对106例颞叶癫痫患者和31名正常受试者进行的脑电图研究表明，这种形式的癫痫在发作间期存在明显的大脑反应性障碍。通过测试定向反射及其习惯化来评估这些障碍，通常表现为反应的躯体、自主神经和脑电图成分增强，对习惯化的抵抗力增加以及习惯化顺序的改变。反应性障碍的严重程度取决于脑电图病灶的定位、发作的临床形式以及发作间期脑电图异常的特征。在发作间期病灶为双侧颞叶、前部或主要为前部（特别是左侧），特别伴有全身性或全身性+部分性发作或刺激性类型的发作间期图形元素的患者中，观察到最明显的反应性障碍。在发作间期病灶为单侧颞叶（特别是右侧）、中部、主要为中部、后部或与部分性发作相关的癫痫患者中，反应性障碍较轻。在少数发作间期生物电活动反映神经兴奋性降低的患者中，反应性障碍表现为反应性降低。颞叶癫痫中反应性改变的不同强度应与致痫性病变确定发作间期弥漫性兴奋性改变的不同能力有关。这种能力取决于癫痫放电所涉及的结构，这些结构因其形态功能特性可影响大脑兴奋性。
