Young James D, Casey Joseph R, Reithmeier Reinhart A F
Department of Physiology, University of Alberta, Edmonton, Canada.
Biochem Cell Biol. 2002;80(5):v-xi. doi: 10.1139/o02-162.
This article summarizes the scientific presentations made at a Canadian Society of Biochemistry and Molecular & Cellular Biology Symposium on "Membrane Proteins in Health and Diseases" and two satellite meetings on "Bicarbonate Transporters" and "Nucleoside Transporters" held in Banff, Alberta, 20-24 March 2002. Membrane proteins are encoded by about 1/3 of genes and are involved in a wide range of essential functions, including the transport of nutrients, ions, and waste products across biological membranes. Mutations or changes in the expression of these genes cause an equally wide range of diseases. Membrane proteins are also common drug targets or provide drug entry mechanisms. The importance of membrane proteins in biology and medicine was highlighted by the presentations made at this exciting meeting by an international group of experts.
本文总结了在2002年3月20日至24日于艾伯塔省班夫举行的加拿大生物化学与分子及细胞生物学协会“健康与疾病中的膜蛋白”专题研讨会以及两场关于“碳酸氢盐转运体”和“核苷转运体”的卫星会议上所做的科学报告。膜蛋白由约三分之一的基因编码,参与广泛的基本功能,包括营养物质、离子和代谢废物跨生物膜的运输。这些基因的突变或表达变化会引发同样广泛的疾病。膜蛋白也是常见的药物靶点或提供药物进入机制。在这次令人兴奋的会议上,国际专家小组的报告突出了膜蛋白在生物学和医学中的重要性。