Teulings F A, Lems P H, Portengen H, Henkelman M S, Blonk D I
Acta Vitaminol Enzymol. 1975;29(1-6):113-6.
Short term cultures of phytohemagglutinin stimulated lymphocytes were used to study effects of tryptophan metabolites of the kynurenine pathway at the cellular level. Only the metabolites 3-hydroxyanthranilic acid and 3-hydroxykynurenine demonstrated an effect when (3H) thymidine was used to monitor the response. Morphological examination of the cultures did not clearly reveal an effect. Because the adenosine triphosphate level was also decreased upon the addition of 3-hydroxyanthranilic acid the possibility is considered that the mechanism of action of the metabolite on cultured lymphocytes can be explained by a suppression of the oxydative phosphorylation.
使用植物血凝素刺激的淋巴细胞短期培养物，在细胞水平上研究犬尿氨酸途径的色氨酸代谢产物的作用。当使用（3H）胸腺嘧啶核苷监测反应时，只有代谢产物3-羟基邻氨基苯甲酸和3-羟基犬尿氨酸显示出作用。对培养物的形态学检查未明确显示出作用。由于添加3-羟基邻氨基苯甲酸后三磷酸腺苷水平也降低，因此认为该代谢产物对培养淋巴细胞的作用机制可以通过氧化磷酸化的抑制来解释。
