犬微小病毒（犬细小病毒）是一种独特的细小病毒，与牛细小病毒最为相似。

The canine minute virus (minute virus of canines) is a distinct parvovirus that is most similar to bovine parvovirus.

作者信息

Schwartz Daniel, Green Bryan, Carmichael Leland E, Parrish Colin R

机构信息

James A. Baker Institute and Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.

出版信息

Virology. 2002 Oct 25;302(2):219-23. doi: 10.1006/viro.2002.1674.

DOI:10.1006/viro.2002.1674

PMID:12441065

Abstract

We characterized the genome and proteins of the canine minute virus (the minute virus of canines (MVC)). The genome sequence showed MVC to be an autonomous parvovirus encoding a large nonstructural protein 1 gene, a smaller nonstructural protein, and overlapping VP1 and VP2 protein genes. The virus was most closely related to bovine parvovirus (BPV), with which it was 43% identical at the DNA sequence level, while the NS1 and VP1 proteins were 33.6 and 41.4% identical to those of BPV, respectively. Spliced messages of the NS1 gene transcripts were detected by RT-PCR. VP1 and VP2 proteins were detected in purified capsids, as were modified versions of each protein, and VP3 was also found in full capsids.

摘要

我们对犬微小病毒（犬细小病毒（MVC））的基因组和蛋白质进行了表征。基因组序列显示MVC是一种自主细小病毒，编码一个大的非结构蛋白1基因、一个较小的非结构蛋白以及重叠的VP1和VP2蛋白基因。该病毒与牛细小病毒（BPV）关系最为密切，在DNA序列水平上与其有43%的同一性，而NS1和VP1蛋白分别与BPV的NS1和VP1蛋白有33.6%和41.4%的同一性。通过RT-PCR检测到了NS1基因转录本的剪接信息。在纯化的衣壳中检测到了VP1和VP2蛋白，以及每种蛋白的修饰形式，并且在完整衣壳中也发现了VP3。