Wang Z, Bhattacharya N, Weaver M, Petersen K, Meyer M, Gapter L, Magnuson N S
School of Molecular Biosciences Washington State University Pullman, Washington 99164-4234, USA.
J Vet Sci. 2001 Dec;2(3):167-79.
Pim-1 belongs to a family of serine/threonine protein kinases that are highly conserved through evolution in multicellular organisms. Originally identified from moloney murine leukemia virus (MuLV)-induced T-cell lymphomas in mice, Pim-1 kinase is involved in the control of cell growth, differentiation and apoptosis. Expression of Pim-1 kinase can be stimulated by a variety of growth factors and regulated at four different levels: transcriptional, post-transcriptional, translational and post-translational. Several signal transduction pathways may be associated with the regulation of Pim-1's expression; accumulating data support that the expression of Pim-1 protein is mediated through activation of JAK/STATs. Recent studies of Pim family kinases indicate that Pim-1 kinase plays important roles outside of the hematopoietic system as well.
Pim-1属于丝氨酸/苏氨酸蛋白激酶家族，在多细胞生物的进化过程中高度保守。Pim-1激酶最初是从小鼠莫洛尼氏鼠白血病病毒（MuLV）诱导的T细胞淋巴瘤中鉴定出来的，它参与细胞生长、分化和凋亡的调控。Pim-1激酶的表达可被多种生长因子刺激，并在转录、转录后、翻译和翻译后四个不同水平上受到调节。几种信号转导途径可能与Pim-1表达的调控有关；越来越多的数据支持Pim-1蛋白的表达是通过JAK/STATs的激活介导的。最近对Pim家族激酶的研究表明，Pim-1激酶在造血系统之外也发挥着重要作用。
