低水平的共受体CCR5足以使HIV包膜介导与静息CD4 T细胞发生融合。

Low levels of co-receptor CCR5 are sufficient to permit HIV envelope-mediated fusion with resting CD4 T cells.

作者信息

Chanel Chantal, Staropoli Isabelle, Baleux Francoise, Amara Ali, Valenzuela-Fernandez Agustin, Virelizier Jean-Louis, Arenzana-Seisdedos Fernando, Altmeyer Ralf

机构信息

Unite de Immunologie Virale, Institut Pasteur, 75015 Paris, France.

出版信息

AIDS. 2002 Nov 22;16(17):2337-40. doi: 10.1097/00002030-200211220-00016.

DOI:10.1097/00002030-200211220-00016

PMID:12441808

Abstract

The susceptibility of phenotypically CCR5-negative resting CD4 T cells for membrane fusion with a CCR5-specific HIV-1 envelope was analysed using a novel sensitive fusion assay. A very low overall density of CCR5 on T cells expressing high levels of CD4 was shown to be sufficient for HIV envelope-mediated membrane fusion. These findings are relevant to the understanding of how HIV-1 R5 strains enter and replicate in resting CD4 T cells in vivo.

摘要

使用一种新型的灵敏融合测定法，分析了表型CCR5阴性的静息CD4 T细胞与CCR5特异性HIV-1包膜进行膜融合的易感性。结果显示，在表达高水平CD4的T细胞上，CCR5的总体密度非常低，这足以介导HIV包膜介导的膜融合。这些发现对于理解HIV-1 R5毒株在体内静息CD4 T细胞中的进入和复制方式具有重要意义。