Gács G
Endokrinologie. 1976 Mar;67(1):85-9.
The effect of congestive cardiac failure, hypoxia and hypoglycaemia on glucose tolerance and insulin secretion were studied in selected groups of infants with congenital heart disease. Fasting blood glucose level was significantly decreased in patients with congestive heart failure and in cyanotic infants without congestive heart failure. In the former it seemed to be correlated with the degree of malnutrition, while in cyanotic infants it was independent of the nutritional state. Plasma insulin levels were reduced in infants, with congestive cardiac failure, although their glucose tolerance test and free fatty acid concentrations were normal. It is suggested that the decreased plasma insulin concentration was a consequence of adaptation to reduced requirements. Glucose tolerance and insulin secretion were not affected by hypoxia or hypoglycaemia.
在选定的先天性心脏病婴儿组中，研究了充血性心力衰竭、缺氧和低血糖对葡萄糖耐量及胰岛素分泌的影响。充血性心力衰竭患儿以及无充血性心力衰竭的青紫型婴儿的空腹血糖水平显著降低。在前者中，这似乎与营养不良程度相关，而在青紫型婴儿中，这与营养状况无关。尽管患有充血性心力衰竭的婴儿葡萄糖耐量试验和游离脂肪酸浓度正常，但其血浆胰岛素水平降低。提示血浆胰岛素浓度降低是对需求减少的适应性结果。葡萄糖耐量和胰岛素分泌不受缺氧或低血糖影响。
