Boivin S, Derdour-Gury H, Perpetue J, Jeandidier N, Pinget M
Service de Médecine Interne D, Hôpital Pasteur, 39, avenue de la Liberté, 68024 Colmar Cedex, France.
Ann Endocrinol (Paris). 2002 Oct;63(5):480-7.
Pregnancies complicated with diabetes mellitus, either previously diagnosed, or appearing during pregnancy, gestational diabetes , present an increased maternofetal risk. An additional risk of fetal malformations exists when diabetes is present before the beginning of pregnancy. Hyperglycemia plays a role in the occurrence of these complications but other factors, more or less identified, could also be implicated. Pregnancy may favor the occurrence or aggravation of diabetic retinopathy and/or nephropathy in patients with pre-existing diabetes. The pathophysiology of gestational diabetes includes insulin resistance and decreased insulin secretion, suggesting some commune aspects with type 2 diabetes. There is no international consensus about screening for gestational diabetes nor for diagnostic criteria. For gestational diabetes as in cases of pre-existing diabetes, treatment principles relay on dietetics and insulin. The improvement in medical care of pregnancies complicated by diabetes includes improvement in scientific knowledge and a specialized medical care of these patients.
妊娠合并糖尿病,无论是先前已诊断的,还是在孕期出现的妊娠糖尿病,都会增加母婴风险。如果在怀孕开始前就存在糖尿病,则胎儿有额外的畸形风险。高血糖在这些并发症的发生中起作用,但其他或多或少已明确的因素也可能与之有关。妊娠可能会促使已患糖尿病的患者发生或加重糖尿病视网膜病变和/或肾病。妊娠糖尿病的病理生理学包括胰岛素抵抗和胰岛素分泌减少,这表明与2型糖尿病有一些共同之处。对于妊娠糖尿病的筛查和诊断标准,目前尚无国际共识。对于妊娠糖尿病以及先前已患糖尿病的情况,治疗原则基于饮食学和胰岛素。改善糖尿病合并妊娠的医疗护理包括提高科学认识以及对这些患者进行专业医疗护理。