糖尿病妊娠中的血糖控制与胎儿胆固醇稳态的关系。
Relation of glucose control in diabetic pregnancy to fetal cholesterol homeostasis.
作者信息
Gordon Yvette, Patterson Tamula M, Parker C Richard
机构信息
Department of Obstetrics and Gynecology, Center for Women's Reproductive Health, University of Alabama, Birmingham, AL, USA.
出版信息
J Matern Fetal Neonatal Med. 2009 Jan;22(1):8-12. doi: 10.1080/14767050802491547.
OBJECTIVE
To determine the impact of maternal diabetic glucose control on fetal cholesterol homeostasis.
METHODS
Singleton pregnancies of 150 women complicated by gestational (n = 90) and pre-gestational (n = 60) diabetes were evaluated. Those with insulin-requiring diabetes had fasting blood glucose levels determined daily during the last 4 weeks of pregnancy and weekly fasting glucose values were obtained in those with A1 (diet-controlled) gestational diabetes. Umbilical cord venous serum was collected at delivery and total cholesterol levels were determined.
RESULTS
Among the 150 women, 69 had A1 gestational diabetes and 81 were insulin-requiring. Fasting glucose levels were inversely correlated (p < 0.001) to gestational age, regardless of diabetes classification. Umbilical serum cholesterol levels were inversely related (p < 0.002) to gestational age and weight, but did not vary according to diabetic classification. Among term infants (n = 110), umbilical serum cholesterol levels were inversely related to maternal fasting glucose levels at 4 weeks (p = 0.006) and 2 weeks (p = 0.006) before delivery.
CONCLUSION
Maternal hyperglycemia is associated with decreased plasma fetal cholesterol levels in term infants.
目的
确定母体糖尿病血糖控制对胎儿胆固醇稳态的影响。
方法
对150例患有妊娠期（n = 90）和孕前（n = 60）糖尿病的单胎妊娠妇女进行评估。那些需要胰岛素治疗的糖尿病患者在妊娠最后4周每天测定空腹血糖水平，而A1（饮食控制）型妊娠期糖尿病患者每周测定空腹血糖值。分娩时采集脐带静脉血清并测定总胆固醇水平。
结果
在这150名妇女中，69例为A1型妊娠期糖尿病，81例需要胰岛素治疗。无论糖尿病分类如何，空腹血糖水平与孕周呈负相关（p < 0.001）。脐带血清胆固醇水平与孕周和体重呈负相关（p < 0.002），但不因糖尿病分类而异。在足月婴儿（n = 110）中，脐带血清胆固醇水平与分娩前4周（p = 0.006）和2周（p = 0.006）时的母体空腹血糖水平呈负相关。
结论
母体高血糖与足月婴儿血浆胎儿胆固醇水平降低有关。
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