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小鼠肝脏和心脏线粒体群体随年龄变化的形态计量学研究。

A morphometric study of age-dependent changes in mitochondrial population of mouse liver and heart.

作者信息

Herbener G H

出版信息

J Gerontol. 1976 Jan;31(1):8-12. doi: 10.1093/geronj/31.1.8.

DOI:10.1093/geronj/31.1.8
PMID:1244408
Abstract

Mitochondria in sections of liver and heart (wall of left ventricle) from C57BL/6J mice, 8, 30 and 43 to 44 mo. old, were analyzed, using sterological techniques. The mitochondrial volume density decreased with age in both tissues: in liver the value estimated as 43 to 44 mo. of age was 65% the value estimated at 8 mo. of age; in the heart the 43 to 44 mo. value was 84% of the 8-mo. value. In both tissues, the decrease in mitochondrial volume density was the result of a decrease in the mitochondrial numerical density; the average volume of the mitochondrion remained constant throughout life.

摘要

利用体视学技术分析了8、30以及43至44月龄C57BL/6J小鼠肝脏和心脏(左心室壁)切片中的线粒体。两个组织中的线粒体体积密度均随年龄增长而降低:在肝脏中,43至44月龄时的估计值为8月龄时估计值的65%;在心脏中,43至44月龄时的值为8月龄时值的84%。在两个组织中,线粒体体积密度的降低是线粒体数量密度降低的结果;线粒体的平均体积在整个生命过程中保持恒定。

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